Atypical parkinsonism in the Caribbean island of Guadeloupe: Etiological role of the mitochondrial complex I inhibitor annonacin
Identifieur interne : 000300 ( France/Analysis ); précédent : 000299; suivant : 000301Atypical parkinsonism in the Caribbean island of Guadeloupe: Etiological role of the mitochondrial complex I inhibitor annonacin
Auteurs : Annie Lannuzel [France] ; Merle Ruberg [France] ; Patrick P. Michel [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-11-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Guadeloupe.
English descriptors
- KwdEn :
- Animals, Electron Transport Complex I (antagonists & inhibitors), Furans (administration & dosage), Guadeloupe, Guadeloupe (epidemiology), Humans, Lactones (administration & dosage), Mitochondria, Mitochondria (drug effects), Mitochondria (metabolism), Nervous system diseases, Neurotoxin, Parkinsonian Disorders (epidemiology), Parkinsonian Disorders (etiology), Parkinsonian Disorders (pathology), Parkinsonism, acetogenin, atypical parkinsonism, mitochondria, neurotoxin, progressive supranuclear palsy.
- MESH :
- chemical , administration & dosage : Furans, Lactones.
- chemical , antagonists & inhibitors : Electron Transport Complex I.
- geographic , epidemiology : Guadeloupe.
- drug effects : Mitochondria.
- epidemiology : Parkinsonian Disorders.
- etiology : Parkinsonian Disorders.
- metabolism : Mitochondria.
- pathology : Parkinsonian Disorders.
- Animals, Humans.
Abstract
On the French West Indian island of Guadeloupe, atypical parkinsonian patients represent two‐thirds of all cases of parkinsonism, which is exceptionally frequent compared to epidemiological data from European countries where atypical parkinsonism accounts for only approximately 5% of all cases. The clinical entity was a unique combination of levodopa‐resistant parkinsonism, tremor, myoclonus, hallucinations, REM sleep behavior disorder and fronto‐subcortical dementia. Based on the presence or the absence of supranuclear gaze palsy, two subgroups of patients were distinguished. In patients with oculomotor signs that came to autopsy, neuronal loss was found to predominate in the substantia nigra and the striatum but other brain areas were also affected, including the frontal cortex. In addition, tau‐containing lesions were detected throughout the brain. Epidemiological data suggested a close association of the disease with the regular consumption of soursop, a tropical annonaceous plant. Experimental studies performed in midbrain cell cultures identified annonacin, a selective mitochondrial complex I inhibitor contained in the fruit and leaves of soursop, as a probable etiological factor. Consistent with this view, chronic administration of annonacin to rats through Alzet osmotic minipumps showed that annonacin was able to reproduce the brain lesions characteristic of the human disease. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22300
Affiliations:
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ISTEX:96F7F738D2AC85FBEFDAE68370B9EC3740C8742CLe document en format XML
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The clinical entity was a unique combination of levodopa‐resistant parkinsonism, tremor, myoclonus, hallucinations, REM sleep behavior disorder and fronto‐subcortical dementia. Based on the presence or the absence of supranuclear gaze palsy, two subgroups of patients were distinguished. In patients with oculomotor signs that came to autopsy, neuronal loss was found to predominate in the substantia nigra and the striatum but other brain areas were also affected, including the frontal cortex. In addition, tau‐containing lesions were detected throughout the brain. Epidemiological data suggested a close association of the disease with the regular consumption of soursop, a tropical annonaceous plant. Experimental studies performed in midbrain cell cultures identified annonacin, a selective mitochondrial complex I inhibitor contained in the fruit and leaves of soursop, as a probable etiological factor. Consistent with this view, chronic administration of annonacin to rats through Alzet osmotic minipumps showed that annonacin was able to reproduce the brain lesions characteristic of the human disease. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name></noRegion><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><name sortKey="Lannuzel, Annie" sort="Lannuzel, Annie" uniqKey="Lannuzel A" first="Annie" last="Lannuzel">Annie Lannuzel</name><name sortKey="Michel, Patrick P" sort="Michel, Patrick P" uniqKey="Michel P" first="Patrick P." last="Michel">Patrick P. Michel</name><name sortKey="Michel, Patrick P" sort="Michel, Patrick P" uniqKey="Michel P" first="Patrick P." last="Michel">Patrick P. Michel</name><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name><name sortKey="Ruberg, Merle" sort="Ruberg, Merle" uniqKey="Ruberg M" first="Merle" last="Ruberg">Merle Ruberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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